Daonil 5mg Tablets - 10 Tablets

Daonil is used to control blood glucose levels in patients with type 2 diabetes mellitus. This type of diabetes is also known as non-insulin-dependent diabetes (NIDDM) or maturity onset diabetes.

Daonil is used in conjunction with diet control and exercise to control blood sugar.

Daonil can be used alone, or in combination with insulin or other anti-diabetes medicines.

Daonil lowers high blood glucose by increasing the amount of insulin released by your pancreas.

Daonil belongs to a group of medicines called sulphonylureas.

If your blood glucose is not properly controlled, you may experience hypoglycaemia (low blood glucose) or hyperglycaemia (high blood glucose). High blood glucose can lead to serious problems with your heart, eyes, circulation or kidneys.

Low blood glucose can occur suddenly. Signs may include:

• weakness, trembling, shaking
• sweating
• light headedness, dizziness, headache or lack of concentration
• tearfulness, crying or depression
• irritability
• hunger
• numbness around the lips and tongue
• restlessness or disturbed sleep
• If not treated promptly, these may progress to:
• loss of co-ordination
• slurred speech
• confusion
• loss of consciousness or seizures High blood glucose usually occurs more slowly than low blood glucose. Signs of high blood glucose may include:
• lethargy or tiredness
• headache
• severe thirst
• passing large amounts of urine and more often
• blurred vision
• dry mouth or dry skin

Ask your doctor if you have any questions about why this medicine has been prescribed for you.

Your doctor may have prescribed it for another reason.

Daonil is not addictive.

Daonil is available only with a doctor's prescription.

This medicine is not expected to affect your ability to drive a car or operate machinery.

There is not enough information to recommend the use of this medicine for children.

Before you take Daonil

When you must not take it

Do not take Daonil if you have an allergy to:

• any medicine containing glibenclamide
• any of the ingredients listed at the end of this leaflet.
• any other similar medicines (such as sulphur antibiotics or sulphonylureas).
• Some of the symptoms of an allergic reaction may include:
• shortness of breath
• wheezing or difficulty breathing
• swelling of the face, lips, tongue or other parts of the body
• rash, itching or hives on the skin

Do not take Daonil if you have any of the following conditions:

• Type 1 diabetes mellitus (insulin-dependent diabetes mellitus, also known as IDDM, or juvenile or growth onset diabetes)
• unstable diabetes
• diabetic ketoacidosis
• diabetic coma or pre-coma
• severe kidney disease
• severe liver disease
• you are being treated with the medication bosentan

Do not take this medicine if you are pregnant.

It may affect your developing baby if you take it during pregnancy.

Insulin is more suitable for controlling blood sugar during pregnancy. Your doctor will replace Daonil with insulin while you are pregnant.

Do not breast-feed if you are taking this medicine.

It is not known if Daonil passes into breast milk. Daonil should not be taken while you are breastfeeding.

Do not give Daonil to children.

Safety and effectiveness in children has not been established.

Do not take this medicine after the expiry date printed on the pack or if the packaging is torn or shows signs of tampering.

If it has expired or is damaged, return it to your pharmacist for disposal.

If you are not sure whether you should start taking this medicine, talk to your doctor.

Before you start to take it

Tell your doctor if you have allergies to any other medicines, foods, preservatives or dyes.

Tell your doctor if you have or have had any of the following medical conditions:

• glucose-6-phosphate (G6PD) deficiency
• a history of diabetic coma
• adrenal, pituitary (or thyroid) problems
• heart failure
• kidney or liver problems
• you drink alcohol in any amount
• you do not eat regular meals
• you do a lot of exercise or heavy work
• you are feeling ill or unwell
• you are taking any other antidiabetic treatment

Diet, exercise, alcohol and your general health all strongly affect the control of your diabetes. Discuss these things with your doctor.

Tell your doctor if you are pregnant or plan to become pregnant or are breast-feeding.

Your doctor can discuss with you the risks and benefits involved.

If you have not told your doctor about any of the above, tell him/her before you start taking Daonil.

Taking other medicines

Tell your doctor or pharmacist if you are taking any other medicines, including medicines that you buy without a prescription from your pharmacy, supermarket or health food shop.

Some medicines may lead to low blood glucose (hypoglycaemia) by increasing the blood glucose lowering effect of Daonil. These include:

• alcohol
• some medicines used to treat high blood pressure
• some medicines used to treat arthritis, pain and inflammation
• (anabolic) steroids
• some cholesterol-lowering medicines
• other medicines used to treat diabetes
• some antibiotics
• medicines used to prevent blood clots
• disopyramide, a medicine used to treat irregular heart rhythms
• some medicines used to treat depression
• pentoxifylline (oxpentifylline), a medicine used to treat blood vessel problems
• some medicines used to treat cancer
• some medicines used to treat gout
• cimetidine and ranitidine, medicines used to treat reflux and ulcers

Some medicines may lead to loss of control of your diabetes (resulting in high blood glucose) by weakening the blood glucose-effect of Daonil. These include:

• alcohol
• some medicines used to treat glaucoma
• some medicines used to treat high blood pressure
• corticosteroids such as prednisone and cortisone
• glucagon, a medicine used to treat low blood glucose
• some medicines used to treat tuberculosis
• high dose nicotinic acid used for the lowering of blood fats
• oestrogens and oral contraceptives
• some medicines used to treat mental illness or psychotic disorders
• phenytoin, a medicine used to treat epilepsy (convulsions)
• cimetidine and ranitidine, medicines used to treat reflux and ulcers
• ritodrine, a medicine used to prevent premature labour
• diuretics, also known as fluid tablets
• some asthma medicines and weight reducing medicines
• thyroid hormones
• large doses of laxatives
• indomethacin, a medicine used to treat arthritis (an inflammatory condition)
• barbiturates, medicines used for sedation

Some medicines may hide the symptoms of low blood sugar (hypoglycaemia). These include:

• alcohol
• some medicines used to treat high blood pressure

You may need different amounts of your medicine or you may need to take different medicines. Your doctor, pharmacist or diabetes educator can tell you what to do if you are taking any of these medicines. They also have a more complete list of medicines to be careful with or avoid while taking Daonil.

Ask your doctor or pharmacist if you are not sure if you are taking any of these medicines.

How to take Daonil

Follow all directions given to you by your doctor, pharmacist or diabetes educator carefully.

They may differ from the information contained in this leaflet.

If you do not understand the instructions on the pack, ask your doctor, pharmacist or diabetes educator for help.

How much to take

Your doctor will tell you how many tablets to take each day. Your doctor may increase or decrease the dose depending on your blood glucose levels.

Note: Please attach your doctor's prescription